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Neurobiology Astrocytes

Astrocytes have an essential function for brain homeostasis and neuroprotection. Together with microglia, astrocytes are a key cell in the clearance of apoptotic neurons and cellular debris, which is connected with several neuropathologies. The ability of astrocytes to adopt either a pro- or anti-inflammatory phenotype highlights their role in the inflammatory response of the CNS. Censo has the skill to configure astrocyte assays which model aspects of the inflammatory response in a range of neurological diseases.

Contact us to learn more about how Censo’s human iPSC derived astrocytes can be used to develop custom disease models.

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Day 75 iPSC-derived astrocytes stained for A2B5

Day 75 iPSC-derived astrocytes stained for EAAT2

Day 75 iPSC-derived astrocytes stained for GFAP (red) and S100β (green)

Astrocyte morphology

Representative images of mature astrocytes stained with specific markers

Astrocyte phagocytosis

Phagocytosis of pHrodo-labelled S. aureus bioparticles in iPSC-derived astrocytes at day 52. The effect of Cytochalasin D, which inhibits actin polymerisation and phagocytosis, is a useful positive control for inhibition in this assay.

Censo’s core technology provides a means of isolating and examining the responses of the key cellular players in neuroinflammation and neurodegeneration. We specialize in bespoke assay development. Please get in touch with the team to discuss in more detail.